News
Student from Bitburg explores drug discovery
05.07.2024
As part of her career orientation internship Dora Molnar, a student from St. Willibrord Gymnasium in Bitburg, was able to join our working group. During this week, she gained exciting insights into everyday scientific laboratory work in human cell culture linking the theoretical knowledge of natural sciences from school into a translational context. In addition, Dora experienced how science combines analytical skills and creativity to achieve significant advances in the field of drug discovery.
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07.06.2024
The Teusch research group is pleased to announce our new article entitled “Novel Histone Deacetylase (HDAC) Inhibitor Induces Apoptosis and Suppresses Invasion via E-cadherin Upregulation in Pancreatic Ductal Adenocarcinoma (PDAC)” which has been published in the journal Pharmaceuticals and is available online:
https://www.mdpi.com/1424-8247/17/6/752
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreatic cancer characterized by therapy resistance and early metastasis, resulting in a low survival rate. Histone deacetylase (HDAC) inhibitors showed potential for the treatment of hematological malignancies. In PDAC, the overexpression of HDAC 2 is associated with the epithelial–mesenchymal transition (EMT), principally accompanied by the downregulation of the epithelial marker E-cadherin and increased metastatic capacity. Our study indicates that the HDAC inhibitor acts by suppressing tumor cell invasion via upregulating E-cadherin mediated by HDAC 2 blockade and by inducing cell cycle arrest leading to apoptosis via HDAC 6 inhibition. Moreover, a synergistic interaction with the chemotherapeutic drug gemcitabine could be demonstrated suggesting that selective HDAC inhibitors might represent a novel strategy for combination therapies of PDAC tumorigenesis and metastasis.
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Fostering the 3R concept in drug discovery
24.04.2024
On April 24th Nicole Teusch had the pleasure of presenting a new 3D organoid-on-chip model developed in collaboration with Dynamic42 GmbH to the scientific advisory board of the set foundation (Foundation for the Promotion of Research on Alternative Methods to Animal Experiments).
An inspiring afternoon with many exciting discussions and new ideas on modern alternative methods in pharmaceutical research.
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New Publication
20.12.2023
Check out our recent publication in Marine Drugs in a Theme Issue Honoring Prof. Peter Proksch`s 70th Birthday: